Li-Huei Tsai is the Picower Professor of Neuroscience at MIT, the director of The Picower Institute for Learning and Memory, and co-director of the Alana Center for Down Syndrome Research. Her lab investigates disorders of memory and cognition, in particular neurodegenerative conditions such as Alzheimer’s disease, at scales ranging from the molecular and cellular to that of circuits and systems. Tsai is a Fellow of the American Association for the Advancement of Science, a Fellow of the National Academy of Inventors, a Member of the National Academy of Medicine, a Member of the American Academy of Arts and Sciences, and an Academician of the Academia Sinica in Taiwan. She is a recipient of the Society for Neuroscience Mika Salpeter Lifetime Achievement Award, and the 2018 Hans Wigzell Research Foundation Science Prize for her research on Alzheimer’s disease